Hot Topic Abstract: ALLERGIC DISORDERS IN SYSTEMIC VASCULITIS

research-article

ALLERGIC DISORDERS IN SYSTEMIC VASCULITIS: A CASE-CONTROLLED STUDY

M. J. CUADRADO, D. D’CRUZ,, M. LLOYD, F. MUJIC, M. A. KHAMASHTA and G. R. V. HUGHES

Lupus Arthritis Research Unit, The Rayne Institute, St Thomas’ Hospital London SEI 7EH

A number of the systemic vasculitides (SV) may have an allergiccomponent although specific allergens remain unknown. We evaluatedthe prevalence of several types of allergy in 60 consecutivepatients with SV and their families Two control groups werestudied. One included 60 healthy people and the other 60 unselectedpatients attending a general rheumatology clinic who did nothave SV. Forty-four of the 60 patients (73%) had a history ofat least one type of allergy. This was significantly higherthan in either control group (P = 0.0001 and P = 0.0002). Therewas also a significantly higher prevalence of allergies amongthe families of the SV patients compared to the controls Thisdata supports the idea that an allergic response to an externalallergen may play an important part in the aetiology of thesediseases

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