Update Reseacrh: Immunomodulating factors in Breastmilk be associated with food alergy

Can the concentration of immunomodulating factors in mature breastmilk be associated with food alergy in breastfed children?

Hogendorf A, et al.

Med Wieku Rozwoj. 2012;16(2):104-108.

Abstract
Objectives: The aim of the study was to determine the concentration of such immunomodulating factors as transforming growth factor beta1 (TGF-β1), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α) in mature human milk and to relate the levels of the above mentioned cytokines in mature breast milk to the occurence of food allergy in children during the first 24 months of life. Materials and methods: Data on breastfeeding, symptoms of food allergy in children and breast milk samples were collected prospectively from birth to 24 months of age from 84 mothers participating in the Polish birth cohort of “EuroPrevall” study, in the years 2005-2007. Cytokine levels were measured in the whey with commercial enzyme-linked immunosorbent assays (ELISA) kits. Results: Ten out of the eighty four (11.9%) participating children had positive SPT and/or sIgE to food antigens. In 7 out of 84 (8.4%) children DBPCFC confirmed the diagnosis of food allergy. The median concentration of TGF-β1 was 21.94 pg/ml (range 10.47-83.19), TNF-α 1.46 pg/ml (range 0.35-16.50), IL- 101.83 pg/ml (range 0.58-31.04). There was a positive correlation between the concentration of IL-10 and TGF-β1. The level of TNF-α correlated positively with the duration of lactation (p=0.04). There was no significant difference between the concentration of IL-10, TGF-β1, TNF-α, in the mature breast milk of mothers of children with symptoms of allergy and positive SPT and/or sIgE, mothers of children with positive DBPCFC and in the milk of mothers of control children. Conclusions: There was no significant difference between the concentration of IL-10, TGF-β1, TNF-α, in the mature breast milk of mothers of children with food allergy and in the breast milk of mothers of control children.

Source: Klinika Pediatrii, Onkologii, Hematologii i Diabetologii Uniwersytetu Medycznego w Łodzi, ul. Sporna 36/50, Łódź,

  • Provided by

    CHILDREN ALLERGY CLINIC ONLINE

    Yudhasmara Foundation htpp://www.allergyclinic.wordpress.com/

    WORKING TOGETHER FOR STRONGER, SMARTER AND HEALTHIER CHILDREN BY EDUCATION, CLINICAL INTERVENTION, RESEARCH AND INFORMATION NETWORKING. Advancing of the future pediatric and future parenting to optimalized physical, mental and social health and well being for fetal, newborn, infant, children, adolescents and young adult

    CLINICAL INTERVENTION AND MEDICAL SERVICES “CHILDREN GRoW UP CLINIC”

    PROFESSIONAL CLINIC “CHILDREN GRoW UP CLINIC”

    • Dr Narulita Dewi SpKFR, Physical Medicine & Rehabilitation
    • Dr Widodo Judarwanto SpA, Pediatrician
    • Fisioterapis

    Clinical and Editor in Chief :

    Dr Widodo Judarwanto, pediatrician email : judarwanto@gmail.com, Curiculum Vitae

    Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.

    Copyright © 2012, Children Allergy Clinic Online Information Education Network. All rights reserved

  • Tinggalkan Balasan

    Isikan data di bawah atau klik salah satu ikon untuk log in:

    Logo WordPress.com

    You are commenting using your WordPress.com account. Logout / Ubah )

    Gambar Twitter

    You are commenting using your Twitter account. Logout / Ubah )

    Foto Facebook

    You are commenting using your Facebook account. Logout / Ubah )

    Foto Google+

    You are commenting using your Google+ account. Logout / Ubah )

    Connecting to %s