Maternal weight, gestational weight gain and preschool wheezing. The Generation R Study.
Leermakers ET, et al.
Eur Respir J. 2013 Mar 7.
We studied the associations of maternal prepregnancy body mass index and gestational weight gain with risks of preschool wheezing in offspring and explored the role of growth, infectious and atopic mechanisms.This sub-study of 4,656 children was embedded in a population-based birth cohort. Information about maternal prepregnancy weight, gestational weight gain and wheezing at the ages 1 to 4 was obtained by physical measurements or questionnaires.Among mothers with a history of asthma or atopy, maternal prepregnancy obesity was associated with an overall increased risk of preschool wheezing (OR 1.47 (1.12, 1.95)). Also, each SD increase of gestational weight gain was associated with an increased overall risk of preschool wheezing (OR 1.09 (1.04, 1.14)), independent of prepregnancy body mass index and not different between mothers with and without a history of asthma or atopy. Child’s growth, respiratory tract infections or eczema did not alter the results.Mothers with prepregnancy obesity and a history of asthma or atopy, and higher gestational weight gain showed higher risks of wheezing in their offspring. These associations could not be explained by growth, infectious or atopic mechanisms. Further research is needed to identify underlying mechanisms and long term consequences.
Source: Erasmus Medical Center, Rotterdam, the Netherlands.
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